When antidepressants and talking therapy haven’t been enough, KAP offers a different way in — combining a fast-acting medicine with the psychological work needed to make change stick.
If you’re reading this, there’s a good chance you’ve already tried more than one antidepressant, sat through months of CBT or counselling, and are still waking up under the same weight.
Roughly a third of people diagnosed with depression don’t reach full remission even after trying two or more antidepressants at an adequate dose — this is what’s clinically defined as treatment-resistant depression (TRD).
If that’s where you are, you’re not failing treatment — the treatment is failing to reach the part of the illness it needs to.
Ketamine creates a window of heightened neuroplasticity. Psychotherapy is what you walk through it with.
Ketamine acts on the glutamate system — not serotonin — rapidly increasing neural connectivity within hours rather than weeks.
A short window opens where the brain is measurably more receptive to forming new patterns, loosening entrenched beliefs and cognitive rigidity.
Structured therapeutic work — IFS, somatic approaches, integrative talking therapy — meets the brain in this receptive state to embed lasting change.
A structured four-stage process, from first assessment to ongoing integration.
Ketamine’s effects are neurological, structural, and psychological. Understanding what happens in the brain explains why conventional antidepressants often fall short.
In depression, the DMN becomes chronically overactive — this is the neurological basis of the loop of negative, self-focused thought. Ketamine temporarily reduces this hyperactivity in a way no conventional antidepressant reliably achieves. Patients often describe a sudden loosening of that internal grip.
By temporarily blocking NMDA receptors, ketamine triggers a rapid surge in glutamate that strengthens synaptic connections in key mood-regulating circuits — particularly in the prefrontal cortex. Effects are measurable within hours, unlike SSRIs which take weeks.
The neurobiological effects converge to create a window of heightened neuroplasticity lasting hours to days post-session. During this window, entrenched negative schemas become more accessible. This is when KAP’s integration session does its most important work.
Therapy can be helpful during challenging seasons, life transitions, or when you want to understand yourself more deeply.
- Chronic stress & exhaustion.
- Compassion fatigue
- Identity loss through caregiving
- Anxiety & low mood
- Depression & persistent low mood
- Emotional dysregulation
- Social anxiety
- Trauma responses
- Occupational burnout
- Treatment-resistant depression
- High-functioning anxiety
- Performance & identity pressure
- Early-onset depression
- PTSD & complex trauma
- Anhedonia & disconnection
- Failed prior antidepressants
Psychotherapist with over ten years of clinical experience, including specialist work in psychedelic-assisted therapies. Co-founded The Ketamine Clinic to bring evidence-based, compassionately delivered KAP to people who haven’t found relief through conventional treatment. MNRPC — National Register of Psychotherapists & Counsellors Dip Hyp CS, O.A. Dip (Psychology) Psychedelic-Assisted Therapy Training, Polaris Insight Center, San Francisco
Trauma surgeon with extensive clinical experience working with ketamine in medical settings. As lead prescriber, Dr Devany is responsible for medical safety, patient assessment, and clinical risk management. All treatment protocols are reviewed and approved under his medical supervision.
